Stanniocalcin 2 antibody (C-Term)

Catalog No. ABIN2789749

This Rabbit Polyclonal antibody specifically detects Stanniocalcin 2 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Dog and Saccharomyces cerevisiae.

Quick Overview for Stanniocalcin 2 antibody (C-Term) (ABIN2789749)

Target: Stanniocalcin 2 (STC2)

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Dog, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stanniocalcin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Stanniocalcin 2 Antibody

Binding Specificity: C-Term

Sequence: PSSRETGRGA KGERGSKSHP NAHARGRVGG LGAQGPSGSS EWEDEQSEYS

Predicted Reactivity: Cow: 100%, Dog: 86%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 89%

Characteristics: This is a rabbit polyclonal antibody against STC2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 302 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Stanniocalcin 2

Target: Stanniocalcin 2 (STC2)

Alternative Name: STC2

Background: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
Alias Symbols: STC-2, STCRP
Protein Interaction Partner: UBC, ELAVL1, POLR2C, POLR3F, ARHGEF40, EIF2B3, CARHSP1, PEBP1, PPP1R8, AIFM1, PTN, ADAM11, ARRB2,
Protein Size: 302

Molecular Weight: 31 kDa

Gene ID: 8614

NCBI Accession: NM_003714, NP_003705

UniProt: O76061

Pathways: Hormone Activity, ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome