Stanniocalcin 2 antibody (N-Term)

Catalog No. ABIN356935

This Rabbit Polyclonal antibody specifically detects Stanniocalcin 2 in WB, IHC (p) and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for Stanniocalcin 2 antibody (N-Term) (ABIN356935)

Target: Stanniocalcin 2 (STC2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stanniocalcin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Stanniocalcin 2 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects STC2 at N-term.

Purification: Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of human STC2

Isotype: Ig Fraction

Application Details

Application Notes: ELISA1: 1,000. Western blotting 1: 100 - 1: 500. Immunohistochemistry: 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for Stanniocalcin 2

Target: Stanniocalcin 2 (STC2)

Alternative Name: Stanniocalcin 2 / STC2

Background: STC2 is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression is induced by estrogen and altered in some breast cancers.Synonyms: STC-2, STC-related protein, STCRP, Stanniocalcin-2, Stanniocalcin-related protein

Molecular Weight: 33249 Da

Gene ID: 8614, 9606

UniProt: O76061

Pathways: Hormone Activity, ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome