PDE4C antibody (C-Term)

Catalog No. ABIN2789817

The Rabbit Polyclonal anti-PDE4C antibody is suitable to detect PDE4C in samples from Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Pig and Rabbit. It has been validated for WB.

Quick Overview for PDE4C antibody (C-Term) (ABIN2789817)

Target: PDE4C (phosphodiesterase 4C, CAMP-Specific (PDE4C))

Reactivity: Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4C antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDE4C Antibody

Binding Specificity: C-Term

Purpose: PDE4C Antibody - C-terminal region

Sequence: RIMAEFFQQG DRERESGLDI SPMCDKHTAS VEKSQVGFID YIAHPLWETW

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 79%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PDE4C. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64361-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDE4C

Target: PDE4C (phosphodiesterase 4C, CAMP-Specific (PDE4C))

Alternative Name: PDE4C

Background:

Background Information: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Name: Phosphodiesterase 4C, cAMP-specific

Alternative Symbols: DPDE1, PDE21

Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Molecular Weight: 68kDa

Gene ID: 5143

NCBI Accession: NP_001092289

UniProt: Q08493

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process