Deoxyguanosine Kinase antibody (C-Term)

Catalog No. ABIN2789830

The Rabbit Polyclonal anti-Deoxyguanosine Kinase antibody (ABIN2789830) specifically detects Deoxyguanosine Kinase in WB. The antibody is reactive with Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig and Rabbit samples.

Quick Overview for Deoxyguanosine Kinase antibody (C-Term) (ABIN2789830)

Target: Deoxyguanosine Kinase (DGUOK)

Reactivity: Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Deoxyguanosine Kinase antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Deoxyguanosine Kinase Antibody

Binding Specificity: C-Term

Purpose: DGUOK Antibody - C-terminal region

Sequence: EQLHGQHEAW LIHKTTKLHF EALMNIPVLV LDVNDDFSEE VTKQEDLMRE

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Pig: 86%, Rabbit: 86%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against DGUOK. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human DGUOK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64409-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Deoxyguanosine Kinase

Target: Deoxyguanosine Kinase (DGUOK)

Alternative Name: DGUOK

Background:

Background Information: In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.

Alternative Symbols: dGK, NCPH, PEOB4, MTDPS3

Protein Name: Deoxyguanosine kinase, mitochondrial

Molecular Weight: 28kDa

Gene ID: 1716

NCBI Accession: NP_550438

UniProt: Q16854

Pathways: Ribonucleoside Biosynthetic Process