gps2 antibody, MGC68832 antibody, MGC63588 antibody, zgc:63588 antibody, GPS2 antibody, MGC133909 antibody, amf-1 antibody, AMF-1 antibody, AI505953 antibody, G protein pathway suppressor 2 antibody, G protein pathway suppressor 2 L homeolog antibody, gps2 antibody, gps2.L antibody, GPS2 antibody, Gps2 antibody
Background
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. Alias Symbols: AMF-1 Protein Size: 327