IDO1 antibody (C-Term)

Catalog No. ABIN2789915

This anti-IDO1 antibody is a Rabbit Polyclonal antibody detecting IDO1 in WB. Suitable for Human, Pig and Rabbit.

Quick Overview for IDO1 antibody (C-Term) (ABIN2789915)

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Reactivity: Human, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IDO1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IDO1 Antibody

Binding Specificity: C-Term

Sequence: ILIPASQQPK ENKTSEDPSK LEAKGTGGTD LMNFLKTVRS TTEKSLLKEG

Predicted Reactivity: Human: 100%, Pig: 79%, Rabbit: 93%

Characteristics: This is a rabbit polyclonal antibody against IDO1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 403 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IDO1

Target: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Alternative Name: IDO1

Background: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Alias Symbols: IDO, INDO, IDO-1
Protein Interaction Partner: UBC, APP, TERF2IP, PPP1R16A, DDX24,
Protein Size: 403

Molecular Weight: 45 kDa

Gene ID: 3620

NCBI Accession: NM_002164, NP_002155

UniProt: P14902

Pathways: Activated T Cell Proliferation