CILP antibody (C-Term)

Catalog No. ABIN2789922

The Rabbit Polyclonal anti-CILP antibody (ABIN2789922) specifically detects CILP in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Horse, Pig and Rabbit samples.

Quick Overview for CILP antibody (C-Term) (ABIN2789922)

Target: CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CILP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CILP Antibody

Binding Specificity: C-Term

Purpose: CILP Antibody - C-terminal region

Sequence: YIKVKIVGPL EVNVRSRNMG GTHRQTVGKL YGIRDVRSTR DRDQPNVSAA

Predicted Reactivity: Cow: 86%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CILP. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP64683-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CILP

Target: CILP (Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP))

Alternative Name: CILP

Background:

Background Information: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins, an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.

Gene Name: Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

Alternative Symbols: CILP-1, HsT18872

Protein Name: Cartilage intermediate layer protein 1

Molecular Weight: 52kDa

Gene ID: 8483

NCBI Accession: NP_003604

UniProt: O75339