FKBP1A antibody (N-Term)

Catalog No. ABIN2790064

The Rabbit Polyclonal anti-FKBP1A antibody (ABIN2790064) specifically detects FKBP1A in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse, Saccharomyces cerevisiae and Zebrafish (Danio rerio) samples.

Quick Overview for FKBP1A antibody (N-Term) (ABIN2790064)

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FKBP1A Antibody

Binding Specificity: N-Term

Purpose: FKBP1A Antibody - N-terminal region

Sequence: GQTCVVHYTG MLEDGKKFDS SRDRNKPFKF MLGKQEVIRG WEEGVAQMSV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against FKBP1A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP65167-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for FKBP1A

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Alternative Name: FKBP1A

Background:

Background Information: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

Gene Name: FK506 binding protein 1A, 12 kDa

Alternative Symbols: FKBP1, PKC12, PKCI2, FKBP12, PPIASE, FKBP-12, FKBP-1A

Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP1A

Molecular Weight: 12kDa

Gene ID: 2280

NCBI Accession: NP_000792

UniProt: P62942

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process