Ephrin A5 antibody (N-Term)

Catalog No. ABIN2790146

Product Details anti-Ephrin A5 Antibody

Target: Ephrin A5 (EFNA5)

Binding Specificity: N-Term

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio), Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ephrin A5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EDSVPEDKTE RYVLYMVNFD GYSACDHTSK GFKRWECNRP HSPNGPLKFS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against EFNA5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human EFNA5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 228 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Ephrin A5

Target: Ephrin A5 (EFNA5)

Alternative Name: EFNA5 (EFNA5 Products)

Synonyms: EFNA5 antibody, af1 antibody, efl5 antibody, rags antibody, eplg7 antibody, lerk7 antibody, AL-1 antibody, AV158822 antibody, EFL-5 antibody, Ephrin-A5 antibody, Epl7 antibody, LERK-7 antibody, RAGS antibody, Lerk7 antibody, AF1 antibody, EFL5 antibody, EPLG7 antibody, GLC1M antibody, LERK7 antibody, ephrin A5 antibody, EFNA5 antibody, efna5 antibody, Efna5 antibody

Background: Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Alias Symbols: AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
Protein Interaction Partner: MYC, GRIP1, SRC, EPHA7, EPHA4, EPHB2, EPHB1, EPHA5, EPHA3, EPHA2, EPHA8,
Protein Size: 228

Molecular Weight: 24 kDa

Gene ID: 1946

NCBI Accession: NM_001962, NP_001953

UniProt: P52803

Pathways: RTK Signaling