SPAG1 antibody (C-Term)
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- Target See all SPAG1 Antibodies
- SPAG1 (Sperm Associated Antigen 1 (SPAG1))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SPAG1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- KIEIQEVNEG KEEPGRPAGE VSMGCLASEK GGKSSRSPED PEKLPIAKPN
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against SPAG1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPAG1
- Top Product
- Discover our top product SPAG1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 926 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SPAG1 (Sperm Associated Antigen 1 (SPAG1))
- Alternative Name
- SPAG1 (SPAG1 Products)
- Synonyms
- cb1089 antibody, MGC162178 antibody, wu:fj78g10 antibody, sp75 antibody, tpis antibody, hsd-3.8 antibody, HSD-3.8 antibody, SP75 antibody, TPIS antibody, sperm associated antigen 1 antibody, sperm associated antigen 1a antibody, SPAG1 antibody, spag1a antibody, CpipJ_CPIJ006297 antibody, spag1 antibody, Spag1 antibody
- Background
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The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization.
Alias Symbols: FLJ32920, HSD-3.8, SP75, TPIS
Protein Interaction Partner: UBC, GNB1, PCNA, PRKCA, DYT10,
Protein Size: 926 - Molecular Weight
- 104 kDa
- Gene ID
- 6674
- NCBI Accession
- NM_003114, NP_003105
- UniProt
- Q07617
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