SPG21 antibody (C-Term)

Catalog No. ABIN2790233

Product Details anti-SPG21 Antibody

Target: SPG21 (Spastic Paraplegia 21 (SPG21))

Binding Specificity: C-Term

Reactivity: Human, Cow, Mouse, Rabbit, Rat, Sheep, Dog, Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG21 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LCRSAEVNLY VQIHLLQFHG TKYAAIDPSM VSAEELEVQK GSLGISQEEQ

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 79%, Rat: 86%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against SPG21. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPG21

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 308 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPG21

Target: SPG21 (Spastic Paraplegia 21 (SPG21))

Alternative Name: SPG21 (SPG21 Products)

Synonyms: ACP33 antibody, GL010 antibody, MAST antibody, BM-019 antibody, C78576 antibody, D9Wsu18e antibody, Maspardin antibody, wu:fd07h02 antibody, zgc:73091 antibody, SPG21, maspardin antibody, spastic paraplegia 21 (autosomal recessive, Mast syndrome) antibody, SPG21, maspardin S homeolog antibody, SPG21 antibody, Spg21 antibody, spg21.S antibody, spg21 antibody

Background: The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.
Alias Symbols: ACP33, BM-019, GL010, MASPARDIN, MAST
Protein Interaction Partner: INCA1, SPRED2, DTX3L, CMTM5, TRIM9, DTX2, REEP6, FAM114A1, ATPAF2, EFHC2, CCDC33, CCDC102B, TRIM54, AGTRAP, CTPS2, S100B, PRPS1, KRT15, CRYAA, TRIM23, CUTC, ARL6IP1, IKZF3, MID2, RABAC1, TFG, TRAF2, TRAF1, TCF12, TCF4, UBC, GSK3A, DHX40, YLPM1, HMGCS1, AK
Protein Size: 308

Molecular Weight: 35 kDa

Gene ID: 51324

NCBI Accession: NM_016630, NP_057714

UniProt: Q9NZD8