RIN2 antibody (N-Term)

Catalog No. ABIN2790373

The Rabbit Polyclonal anti-RIN2 antibody (ABIN2790373) specifically detects RIN2 in WB. The antibody is reactive with Human, Mouse, Cow, Horse, Pig, Rat and Dog samples.

Quick Overview for RIN2 antibody (N-Term) (ABIN2790373)

Target: RIN2 (Ras and Rab Interactor 2 (RIN2))

Reactivity: Human, Mouse, Cow, Horse, Pig, Rat, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RIN2 Antibody

Binding Specificity: N-Term

Sequence: RTDVNLENGL EPAETHSMVR HKDGGYSEEE DVKTCARDSG YDSLSNRLSI

Predicted Reactivity: Cow: 80%, Dog: 80%, Horse: 80%, Human: 100%, Mouse: 83%, Pig: 80%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against RIN2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of human RIN2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RIN2

Target: RIN2 (Ras and Rab Interactor 2 (RIN2))

Alternative Name: RIN2

Background: The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
Alias Symbols: MACS, RASSF4
Protein Size: 462

Molecular Weight: 50 kDa

Gene ID: 54453

NCBI Accession: NM_001242581, NP_001229510

UniProt: Q8WYP3