RIN2 antibody (AA 70-150)

Catalog No. ABIN7231058

This Rabbit Polyclonal antibody specifically detects RIN2 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for RIN2 antibody (AA 70-150) (ABIN7231058)

Target: RIN2 (Ras and Rab Interactor 2 (RIN2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RIN2 Antibody

Binding Specificity: AA 70-150

Purpose: Rabbit Anti-RIN2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RIN2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RIN2 protein at AA range: 70-150

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RIN2

Target: RIN2 (Ras and Rab Interactor 2 (RIN2))

Alternative Name: RIN2

Background: Ras and Rab interactor 2, Ras association domain family 4, Ras inhibitor JC265, Ras interaction/interference protein 2The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by RIN2 (Ras And Rab Interactor 2) binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in RIN2 cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.

Molecular Weight: 98kD

Gene ID: 54453

UniProt: Q8WYP3