D2HGDH antibody (C-Term)

Catalog No. ABIN2790469

This Rabbit Polyclonal antibody specifically detects D2HGDH in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Horse and Pig.

Quick Overview for D2HGDH antibody (C-Term) (ABIN2790469)

Target: D2HGDH (D-2-Hydroxyglutarate Dehydrogenase (D2HGDH))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This D2HGDH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-D2HGDH Antibody

Binding Specificity: C-Term

Sequence: QESPFYVLIE TSGSNAGHDA EKLGHFLEHA LGSGLVTDGT MATDQRKVKM

Predicted Reactivity: Dog: 79%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 77%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against D2HGDH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human D2HGDH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 521 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for D2HGDH

Target: D2HGDH (D-2-Hydroxyglutarate Dehydrogenase (D2HGDH))

Alternative Name: D2HGDH

Background: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
Alias Symbols: D2HGD, FLJ42195, MGC25181
Protein Interaction Partner: SUMO1, UBC,
Protein Size: 521

Molecular Weight: 55 kDa

Gene ID: 728294

NCBI Accession: NM_152783, NP_689996

UniProt: Q8N465