D2HGDH antibody (D-2-Hydroxyglutarate Dehydrogenase) (C-Term)

Details for Product anti-D2HGDH Antibody No. ABIN2790469
Target
Binding Specificity
C-Term
4
4
1
1
1
1
Reactivity
Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
11
5
4
2
2
1
1
1
1
1
Host
Rabbit
15
1
Clonality
Polyclonal
Conjugate
This D2HGDH antibody is un-conjugated
2
2
2
Application
Western Blotting (WB)
11
9
3
2
1
1
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the C-terminal region of Human D2HGDH
Blocking Peptide Blocking peptide for this product available: ABIN1541535
Sequence QESPFYVLIE TSGSNAGHDA EKLGHFLEHA LGSGLVTDGT MATDQRKVKM
Predicted Reactivity Dog: 79%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 77%, Rabbit: 100%, Rat: 92%
Characteristics This is a rabbit polyclonal antibody against D2HGDH. It was validated on Western Blot.
Purification Affinity Purified
Target
Alternative Name D2HGDH (D2HGDH Antibody Abstract)
Background This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
Alias Symbols: D2HGD, FLJ42195, MGC25181
Protein Interaction Partner: SUMO1, UBC,
Protein Size: 521
Molecular Weight 55 kDa
Gene ID 728294
NCBI Accession NM_152783, NP_689996
UniProt Q8N465
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 521 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images
Image no. 1 for anti-D-2-Hydroxyglutarate Dehydrogenase (D2HGDH) (C-Term) antibody (ABIN2790469) WB Suggested Anti-D2HGDH Antibody Titration: 1.0 ug/ml Positive Control: PANC1 Whole ...