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MYSM1 antibody (C-Term)

MYSM1 Reactivity: Human, Dog, Rabbit WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2790657
  • Target See all MYSM1 Antibodies
    MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
    Binding Specificity
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    Human, Dog, Rabbit
    Host
    • 34
    Rabbit
    Clonality
    • 34
    Polyclonal
    Conjugate
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MYSM1 antibody is un-conjugated
    Application
    • 21
    • 21
    • 14
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    CLQKLLECMR KTLSKVTNCF MAEEFLTEIE NLFLSNYKSN QENGVTEENC
    Predicted Reactivity
    Dog: 86%, Human: 100%, Rabbit: 77%
    Characteristics
    This is a rabbit polyclonal antibody against MYSM1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYSM1
    Top Product
    Discover our top product MYSM1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 828 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))
    Alternative Name
    MYSM1 (MYSM1 Products)
    Synonyms
    2A-DUB antibody, 2ADUB antibody, RP4-592A1.1 antibody, C130067A03Rik antibody, C530050H10Rik antibody, RGD1311787 antibody, 2adub antibody, Myb like, SWIRM and MPN domains 1 antibody, myb-like, SWIRM and MPN domains 1 antibody, Myb like, SWIRM and MPN domains 1 L homeolog antibody, MYSM1 antibody, Mysm1 antibody, mysm1.L antibody
    Background
    MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
    Alias Symbols: 2A-DUB, 2ADUB, DKFZp779J1554, DKFZp779J1721, KIAA1915, RP4-592A1.1
    Protein Interaction Partner: UBC, DICER1, SUMO2, TUBB1, WDR77, STK38, PRMT5, KAT2B, HIST2H2AC, RBM10, KIF11, HSPA1A, HNRNPH1, EEF1A1,
    Protein Size: 828
    Molecular Weight
    91 kDa
    Gene ID
    114803
    NCBI Accession
    NM_001085487, NP_001078956
    UniProt
    Q5VVJ2
    Pathways
    Chromatin Binding
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