MYSM1 antibody (C-Term)

Catalog No. ABIN2790657

This Rabbit Polyclonal antibody specifically detects MYSM1 in WB. It exhibits reactivity toward Human, Dog and Rabbit.

Quick Overview for MYSM1 antibody (C-Term) (ABIN2790657)

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Reactivity: Human, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYSM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MYSM1 Antibody

Binding Specificity: C-Term

Purpose: MYSM1 Antibody - C-terminal region

Sequence: CLQKLLECMR KTLSKVTNCF MAEEFLTEIE NLFLSNYKSN QENGVTEENC

Predicted Reactivity: Dog: 86%, Human: 100%, Rabbit: 77%

Characteristics: This is a rabbit polyclonal antibody against MYSM1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYSM1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP67188-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MYSM1

Target: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Alternative Name: MYSM1

Background:

Background Information: MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.

Alternative Symbols: 2ADUB, BMFS4, 2A-DUB

Protein Name: Histone H2A deubiquitinase MYSM1

Molecular Weight: 91kDa

Gene ID: 114803

NCBI Accession: NP_001078956

UniProt: Q5VVJ2

Pathways: Chromatin Binding