PDZD3 antibody (N-Term)

Catalog No. ABIN2791849

Product Details anti-PDZD3 Antibody

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Horse, Pig, Rabbit, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDZD3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PDPWSLERPR FCLLSKEEGK SFGFHLQQEL GRAGHVVCRV DPGTSAQRQG

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PDZD3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PDZD3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDZD3

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Alternative Name: PDZD3 (PDZD3 Products)

Synonyms: RGD1559807 antibody, zgc:194812 antibody, IKEPP antibody, NHERF4 antibody, PDZK2 antibody, NaPi-Cap2 antibody, Pdzk2 antibody, PDZ domain containing 3 antibody, PDZ domain containing 3b antibody, Pdzd3 antibody, pdzd3b antibody, PDZD3 antibody

Background: Guanylyl cyclase C (GCC, or GUCY2C, MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR, MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation.
Protein Interaction Partner: SPRYD7, ASAP3, SLC41A3, CACNA1S, PTGIR, SLC22A4, SLCO1A2, SLC15A2, SLCO1C1, GUCY2C, SLCO3A1, SLC22A9, SLC22A3, SLC22A5, CFTR, ABCC2, SLC15A1,
Protein Size: 386

Molecular Weight: 42 kDa

Gene ID: 79849