PDZD3 antibody (C-Term)

Catalog No. ABIN2791850

The Rabbit Polyclonal anti-PDZD3 antibody is suitable to detect PDZD3 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Pig and Rabbit. It has been validated for WB.

Quick Overview for PDZD3 antibody (C-Term) (ABIN2791850)

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDZD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDZD3 Antibody

Binding Specificity: C-Term

Sequence: APLAEGWALP TKPRCLHLEK GPQGFGFLLR EEKGLDGRPG QFLWEVDPGL

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against PDZD3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PDZD3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PDZD3

Target: PDZD3 (PDZ Domain Containing 3 (PDZD3))

Alternative Name: PDZD3

Background: Guanylyl cyclase C (GCC, or GUCY2C, MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR, MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation.
Protein Interaction Partner: SPRYD7, ASAP3, SLC41A3, CACNA1S, PTGIR, SLC22A4, SLCO1A2, SLC15A2, SLCO1C1, GUCY2C, SLCO3A1, SLC22A9, SLC22A3, SLC22A5, CFTR, ABCC2, SLC15A1,
Protein Size: 571

Molecular Weight: 62 kDa

Gene ID: 79849

UniProt: Q86UT5