GCM2 antibody (N-Term)

Catalog No. ABIN2792067

The Rabbit Polyclonal anti-GCM2 antibody is suitable to detect GCM2 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for GCM2 antibody (N-Term) (ABIN2792067)

Target: GCM2 (Glial Cells Missing Homolog 2 (GCM2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCM2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GCM2 Antibody

Binding Specificity: N-Term

Purpose: GCM2 Antibody - N-terminal region

Sequence: HSGYPVTNFW RLDGNAIFFQ AKGVHDHPRP ESKSETEARR SAIKRQMASF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against GCM2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GCM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP72751-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GCM2

Target: GCM2 (Glial Cells Missing Homolog 2 (GCM2))

Alternative Name: GCM2

Background:

Background Information: This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.

Alternative Symbols: FIH2, GCMB, HRPT4, hGCMb

Molecular Weight: 57kDa

Gene ID: 9247

NCBI Accession: NP_004743

UniProt: O75603