beta 2 Adrenergic Receptor antibody (Middle Region)

Catalog No. ABIN2792089

There is 1 publication for this product available. The Rabbit Polyclonal anti-beta 2 Adrenergic Receptor antibody is suitable to detect beta 2 Adrenergic Receptor in samples from Human. It has been validated for WB.

Quick Overview for beta 2 Adrenergic Receptor antibody (Middle Region) (ABIN2792089)

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta 2 Adrenergic Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-beta 2 Adrenergic Receptor Antibody

Binding Specificity: Middle Region

Sequence: TGEQSGYHVE QEKENKLLCE DLPGTEDFVG HQGTVPSDNI DSQGRNCSTN

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ADRB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ADRB2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 413 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-beta 2 Adrenergic Receptor antibody (ABIN2792089)

Penco, Buscema, Patrosso, Marocchi, Grossi: "New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background." in: BMC bioinformatics, Vol. 9, pp. 254, (2008) (PubMed).

Target Details for beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Alternative Name: ADRB2

Background: This protein is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Protein Interaction Partner: ARRDC3, REL, TSHR, TSG101, STAT4, STAT3, SNCG, RGS10, RGS2, RAN, RAB27A, RAB3A, CNN1, CD81, CD68, CD9, CD4, CCKBR, CEACAM1, ARRB2, ARHGDIA, ARHGAP5, HDAC6, GPR56, VAPA, RGS9, RGS11, RGS20, RGS5, VEGFB, VDAC2, VDAC1, KCTD13, ARRDC1, RGS8, SLC52A2, WNK1, RA
Protein Size: 413

Molecular Weight: 46 kDa

Gene ID: 154

NCBI Accession: NM_000024, NP_000015

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation