CHM antibody (N-Term)

Catalog No. ABIN2792245

There is 1 publication for this product available. The Rabbit Polyclonal anti-CHM antibody is suitable to detect CHM in samples from Human and Horse. It has been validated for WB.

Quick Overview for CHM antibody (N-Term) (ABIN2792245)

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Reactivity: Human, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHM antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHM Antibody

Binding Specificity: N-Term

Purpose: CHM Antibody - N-terminal region

Sequence: LHVDSRSYYG GNWASFSFSG LLSWLKEYQE NSDIVSDSPV WQDQILENEE

Predicted Reactivity: Horse: 80%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CHM. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-CHM antibody (ABIN2792245)

Ishiguro, Yamamoto, Fujita, Akasu, Kobayashi, Moriya: "Effect of a clinical pathway after laparoscopic surgery for colorectal cancer." in: Hepato-gastroenterology, Vol. 55, Issue 85, pp. 1315-9, (2008) (PubMed).

Target Details for CHM

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Alternative Name: CHM

Background:

Background Information: CHM binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.The choroideremia gene encodes for a protein, the Rab escort protein-1 (REP1), which is involved in membrane trafficking.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Choroideremia (Rab escort protein 1)

Alternative Symbols: TCD, GGTA, REP-1, DXS540, HSD-32

Protein Name: Rab proteins geranylgeranyltransferase component A 1

Molecular Weight: 73kDa

Gene ID: 1121

NCBI Accession: NP_000381

UniProt: P24386

Pathways: Sensory Perception of Sound