PAK1 antibody (pThr423)

Catalog No. ABIN2794204

This Rabbit Polyclonal antibody specifically detects PAK1 in IF and DB. It exhibits reactivity toward Human.

Quick Overview for PAK1 antibody (pThr423) (ABIN2794204)

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK1 antibody is un-conjugated

Application: Immunofluorescence (IF), Dot Blot (DB)

Product Details anti-PAK1 Antibody

Binding Specificity: pThr423

Purpose: Rabbit Anti-Human Phospho-PAK1(T423) Antibody

Immunogen: This PAK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T423 of human PAK1.

Isotype: Ig Fraction

Application Details

Application Notes: Immunofluorescence, Dot Blot
Recommended Dilutions
IF: 1:10-50, DB: 1:500Confocal immunofluorescent analysis of Phospho-PAK1-pT423 Antibody on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 μg per ml.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.460 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for PAK1

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Alternative Name: PAK1

Background:

Target Description: PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.

Gene Symbol: PAK1

Molecular Weight: 60647 Da

Gene ID: 5058

UniProt: Q13153

Pathways: MAPK Signaling, RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis