Neuregulin 3 antibody (C-Term)

Catalog No. ABIN2794837

This Rabbit Polyclonal antibody specifically detects Neuregulin 3 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Neuregulin 3 antibody (C-Term) (ABIN2794837)

Target: Neuregulin 3 (NRG3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Neuregulin 3 Antibody

Binding Specificity: AA 688-717, C-Term

Purpose: Rabbit Anti-Human NRG3 (C-term) Antibody

Immunogen: This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids from the C-terminal region of human NRG3.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50NRG3 Antibody (E703) for immunohistochemistry. Clinical relevance has not been evaluated.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for Neuregulin 3

Target: Neuregulin 3 (NRG3)

Alternative Name: NRG3

Background:

Target Description: NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Gene Symbol: NRG3

Molecular Weight: 77901 Da

Gene ID: 10718

UniProt: P56975

Pathways: RTK Signaling