CRTC2 antibody (N-Term)

Catalog No. ABIN2798540

The Rabbit Polyclonal anti-CRTC2 antibody has been validated for WB and IHC. It is suitable to detect CRTC2 in samples from Human.

Quick Overview for CRTC2 antibody (N-Term) (ABIN2798540)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRTC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CRTC2 Antibody

Binding Specificity: AA 94-123, N-Term

Purpose: Rabbit Anti-Human CRTC2 (N-term) Antibody

Immunogen: This CRTC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the N-terminal region of human CRTC2.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50CRTC2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.420 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Alternative Name: CRTC2

Background:

Target Description: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Symbol: CRTC2

Molecular Weight: 73302 Da

Gene ID: 200186

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis