POLG antibody (C-Term)

Catalog No. ABIN2798829

This anti-POLG antibody is a Rabbit Polyclonal antibody detecting POLG in WB, IHC, IF and FACS. Suitable for Mouse.

Quick Overview for POLG antibody (C-Term) (ABIN2798829)

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-POLG Antibody

Binding Specificity: AA 1120-1148, C-Term

Purpose: Rabbit Anti-Mouse POLG (C-term) Antibody

Immunogen: This POLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Flow Cytometry, Immunofluorescence, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, FC: 1:10-50, IF: 1:10-50, IHC: 1:10-50POLG Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.460 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for POLG

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Alternative Name: POLG

Background:

Target Description: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene Symbol: POLG

Molecular Weight: 139562 Da

Gene ID: 5428

UniProt: P54098