Connexin 31 antibody (C-Term)

Catalog No. ABIN2798868

The Rabbit Polyclonal anti-Connexin 31 antibody (ABIN2798868) specifically detects Connexin 31 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Connexin 31 antibody (C-Term) (ABIN2798868)

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Connexin 31 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Connexin 31 Antibody

Binding Specificity: AA 227-257, C-Term

Purpose: Rabbit Anti-Human Connexin 31 (C-term) Antibody

Immunogen: This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100Western blot analysis of hGJB3-C241 Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated. BC = breast carcinoma, HC = hepatocarcinoma.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.0 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for Connexin 31

Target: Connexin 31 (GJB3) (Gap Junction Protein, beta 3, 31kDa (GJB3))

Alternative Name: Connexin 31

Background:

Target Description: Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Gene Symbol: GJB3

Molecular Weight: 30818 Da

Gene ID: 2707

UniProt: O75712

Pathways: Sensory Perception of Sound