NAMPT antibody (AA 400-426)

Catalog No. ABIN2842612

There are 2+ publications for this product available. The Rabbit Polyclonal anti-NAMPT antibody is suitable to detect NAMPT in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for NAMPT antibody (AA 400-426) (ABIN2842612)

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAMPT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB22920

Product Details anti-NAMPT Antibody

Binding Specificity: AA 400-426

Predicted Reactivity: M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NAMPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-426 amino acids from the Central region of human NAMPT.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-NAMPT antibody (ABIN2842612)

Zhang, Tong, Huang: "Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells." in: PLoS ONE, Vol. 8, Issue 7, pp. e69963, (2013) (PubMed).

Pittelli, Formentini, Faraco, Lapucci, Rapizzi, Cialdai, Romano, Moneti, Moroni, Chiarugi: "Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 34106-14, (2010) (PubMed).

Target Details for NAMPT

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Alternative Name: NAMPT

Background: NAMPT catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Molecular Weight: 55521

Gene ID: 10135

NCBI Accession: NP_005737

UniProt: P43490