ABI1 antibody

Catalog No. ABIN1449186

The Mouse Monoclonal anti-ABI1 antibody (Clone 1B9) (ABIN1449186) specifically detects ABI1 in WB, IP and IHC (p). The antibody is reactive with Human, Mouse and Hamster samples.

Quick Overview for ABI1 antibody (ABIN1449186)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reactivity: Human, Mouse, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1B9

Product Details anti-ABI1 Antibody

Specificity: This antibody reacts with Abi-1.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Hamster

Purification: Protein A agarose

Immunogen: Human recombinant Abi-1 expressed in E. coli

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Upon receipt, store (in aliqouts) at -20 °C.

Target Details for ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Alternative Name: ABI1 / SSH3BP1

Background: Abl interactor (Abi) proteins are c-Abl-binding proteins that bind to both the Src homology 3 (SH3) domain and the C-terminal proline-rich regions of Abl kinase through dual SH3-PXXP interactions. Two highly related genes, abi-1 and abi-2, were cloned. In addition to the interaction with Abl kinase, Abi proteins also interact with other signaling molecules. Recently, it has been reported that Abi-1 dramatically promoted c-Abl-mediated tyrosine (Tyr296) phosphorylation of Mena [mammalian homologue of Drosophila Enabled (Ena)] by interacting with both proteins.Synonyms: Abelson interactor 1, Abi-1, Abl interactor 1, Abl-binding protein 4, AblBP4, Eps8 SH3 domain-binding protein, Nap1-binding protein, Spectrin SH3 domain-binding protein 1, Spectrin binding protein, e3B1

Molecular Weight: 65 kDa

Gene ID: 10006

NCBI Accession: NP_001012768

UniProt: Q8IZP0

Pathways: RTK Signaling, Response to Water Deprivation, ER-Nucleus Signaling