NEUROD1 antibody (N-Term)

Catalog No. ABIN2853626

This anti-NEUROD1 antibody is a Rabbit Polyclonal antibody detecting NEUROD1 in IHC (p) and EIA. Suitable for Human.

Quick Overview for NEUROD1 antibody (N-Term) (ABIN2853626)

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEUROD1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-NEUROD1 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects NeuroD1at N-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NeuroD1.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for NEUROD1

Target: NEUROD1 (Neuronal Differentiation 1 (NEUROD1))

Alternative Name: NEUROD1

Background: NeuroD1 acts as a differentiation factor during neurogenesis. They are expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation. NeuroD1 is a basic helix-loop-helix (bHLH) protein contain 1 bHLH domain. NeuroD1 is a transcriptional activator, for efficient DNA binding it requires dimerization with another bHLH protein. It was reported that NeuroD1 involves heterodimerization with the ubiquitous bHLH protein E47, and regulates insulin gene expression by binding to a critical E-box motif on the insulin promoter. Defects in NEUROD1 causes maturity onset diabetes of the young type VI. MODY6 is a form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.Synonyms: NEUROD, NEUROD1, Neurogenic differentiation factor 1

Molecular Weight: 39890 Da

Gene ID: 4760, 9606

UniProt: Q13562

Pathways: Dopaminergic Neurogenesis, Hormone Transport, Carbohydrate Homeostasis