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LIG1 antibody (C-Term)

LIG1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854412
  • Target See all LIG1 Antibodies
    LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))
    Binding Specificity
    • 13
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 63
    • 16
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 55
    • 9
    • 1
    Rabbit
    Clonality
    • 48
    • 17
    Polyclonal
    Conjugate
    • 36
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This LIG1 antibody is un-conjugated
    Application
    • 44
    • 29
    • 15
    • 8
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Human
    Characteristics
    Rabbit polyclonal antibody to DNA ligase I (ligase I, DNA, ATP-dependent)
    DNA ligase I antibody [C2C3], C-term
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human DNA ligase I. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product LIG1 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: A431 , H1299

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Liddiard, Ruis, Kan, Cleal, Ashelford, Hendrickson, Baird: "DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase." in: Nucleic acids research, Vol. 47, Issue 5, pp. 2402-2424, (2019) (PubMed).

  • Target
    LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))
    Alternative Name
    DNA ligase 1 (LIG1 Products)
    Synonyms
    ATLIG1 antibody, DNA ligase 1 antibody, T6D22.23 antibody, ligI antibody, AL033288 antibody, LigI antibody, lig1 antibody, wu:fc54a11 antibody, DNA ligase 1 antibody, DNA ligase 1, putative antibody, ligase I, DNA, ATP-dependent L homeolog antibody, ligase I, DNA, ATP-dependent antibody, LIG1 antibody, PB000674.02.0 antibody, PTRG_06243 antibody, PKH_140260 antibody, lig1.L antibody, Lig1 antibody, lig-1 antibody, lig1 antibody
    Background
    LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

    Cellular Localization: Nucleus
    Molecular Weight
    102 kDa
    Gene ID
    3978
    UniProt
    P18858
    Pathways
    Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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