IL12RB2 antibody

Catalog No. ABIN2854423

This Rabbit Polyclonal antibody specifically detects IL12RB2 in WB. It exhibits reactivity toward Human.

Quick Overview for IL12RB2 antibody (ABIN2854423)

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL12RB2 Antibody

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to IL-12 Receptor beta2 (interleukin 12 receptor, beta 2)
IL-12 Receptor beta2 antibody [N3C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human IL12 Receptor beta2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: A431 , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for IL12RB2

Target: IL12RB2 (Interleukin 12 Receptor, beta 2 (IL12RB2))

Alternative Name: interleukin 12 receptor subunit beta 2

Background: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

Cellular Localization: Membrane, Single-pass type I membrane protein

Molecular Weight: 97 kDa

Gene ID: 3595

UniProt: Q99665

Pathways: JAK-STAT Signaling