This peptide sequence is used when generating the antibody and has no significant homology with UPC1 or UPC3. Predicted cross reactivity is based on rat, hamster at 100% and human, pig, bovine, canine at 86%.
Cross-Reactivity
Mouse (Murine)
Purification
purified
Immunogen
Endothelin A receptor antibody was raised in sheep using C-terminal peptide QEQNHNTERSSHK residues 410 - 422 of rat ET(A) Receptor conjugated to KLH as the immunogen.
IC: 10-20 µg/mL, IF: 10-20 µg/mL, IHC: 10-20 µg/mL, IP: 20-40 µg/mL Optimal conditions should be determined by the investigator.
Restrictions
For Research Use only
Concentration
Lot specific
Buffer
Protein G purified and supplied in PBS, pH 7.5.
Handling Advice
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C.
Lampmann, Borger, Konczalla, Gispert, Auburger, Vatter, Güresir: "Experimental Induction of Intracranial Aneurysms in Rats: A New Model Utilizing a Genetic Modification within the EDNRA Gene." in: Brain sciences, Vol. 12, Issue 9, (2022) (PubMed).
Target
Endothelin-1 Receptor (EDNRA)
(Endothelin Receptor Type A (EDNRA))
Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for endothelins are widely expressed on tissues.