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p63 antibody

KO Validated TP63 Reactivity: Human WB, IF, ICC, IP, IHC (p), IHC (fro), PLA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855394
  • Target See all p63 (TP63) Antibodies
    p63 (TP63) (Tumor Protein P63 (TP63))
    Reactivity
    • 69
    • 24
    • 22
    • 4
    • 2
    • 2
    Human
    Host
    • 53
    • 20
    • 1
    Rabbit
    Clonality
    • 43
    • 31
    Polyclonal
    Conjugate
    • 59
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This p63 antibody is un-conjugated
    Application
    • 45
    • 30
    • 21
    • 15
    • 12
    • 11
    • 11
    • 10
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Proximity Ligation Assay (PLA)
    Cross-Reactivity
    Dog, Human, Mouse, Rat
    Characteristics
    Rabbit Polyclonal antibody to p63 (tumor protein p63)
    p63 antibody [N2C1], Internal
    Purification
    Purified by antigen-affinity chromatography.
    Grade
    KO Validated
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human p63. The exact sequence is proprietary.
    Isotype
    IgG
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: mouse brain , rat brain , A431

    Validation: KO/KD, Orthogonal

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.58 mg/mL
    Buffer
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Kim, Dollé, Vermeij, Gyenis, Vogel, Hoeijmakers, Wiley, Davalos, Hasty, Desprez, Campisi: "Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin." in: Aging cell, Vol. 19, Issue 3, pp. e13072, (2020) (PubMed).

    Li, Wang, Torkelson, Shankar, Pattison, Zhen, Fang, Duren, Xin, Gaddam, Melo, Piekos, Li, Liaw, Chen, Li, Wernig, Wong, Chang, Oro: "TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment." in: Cell stem cell, Vol. 24, Issue 2, pp. 271-284.e8, (2020) (PubMed).

    Jiang, Zhu, He, Gao, Tian, Ma, Wu, Das, Severinov, Hitzeroth, Debata, Liu, Zou, Shi, Xu, Wang, Bao, Ka-Kit, You, Cui, Hu: "Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women." in: Translational oncology, Vol. 12, Issue 7, pp. 959-967, (2019) (PubMed).

    Montoro, Haber, Biton, Vinarsky, Lin, Birket, Yuan, Chen, Leung, Villoria, Rogel, Burgin, Tsankov, Waghray, Slyper, Waldman, Nguyen, Dionne, Rozenblatt-Rosen, Tata, Mou, Shivaraju, Bihler, Mense et al.: "A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. ..." in: Nature, Vol. 560, Issue 7718, pp. 319-324, (2019) (PubMed).

    Xiong, Ren, Chen, Liu, Huang, Zhang, Odera, Chen, Kist, Peters, Garman, Sun, Chen: "PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium." in: The Journal of pathology, Vol. 244, Issue 2, pp. 164-175, (2019) (PubMed).

    OBrien, Dorsey, Hannan, Hultgren: "Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner." in: PLoS pathogens, Vol. 14, Issue 12, pp. e1007457, (2019) (PubMed).

    Reneker, Wang, Irlmeier, Huang: "Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse." in: Investigative ophthalmology & visual science, Vol. 58, Issue 5, pp. 2638-2646, (2017) (PubMed).

    OBrien, Hannan, Yu, Livny, Roberson, Schwartz, Souza, Mendelsohn, Colonna, Lewis, Hultgren: "A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease." in: Nature microbiology, Vol. 2, pp. 16196, (2016) (PubMed).

  • Target
    p63 (TP63) (Tumor Protein P63 (TP63))
    Alternative Name
    tumor protein p63 (TP63 Products)
    Synonyms
    AIS antibody, B(p51A) antibody, B(p51B) antibody, EEC3 antibody, KET antibody, LMS antibody, NBP antibody, OFC8 antibody, RHS antibody, SHFM4 antibody, TP53CP antibody, TP53L antibody, TP73L antibody, p40 antibody, p51 antibody, p53CP antibody, p63 antibody, p73H antibody, p73L antibody, TP63 antibody, tp63 antibody, DNp63 antibody, id:ibd3516 antibody, tp73l antibody, wu:fc89f04 antibody, wu:fk85h07 antibody, wu:fk88b02 antibody, Ket antibody, P73l antibody, Tp73l antibody, Trp63 antibody, TRP63 antibody, AI462811 antibody, P51/P63 antibody, P63 antibody, Tp63 antibody, Trp53rp1 antibody, Xp63 antibody, ket antibody, np63 antibody, tp73l-A antibody, trp63 antibody, tumor protein p63 antibody, transformation related protein 63 antibody, tumor protein p63 L homeolog antibody, TP63 antibody, tp63 antibody, Tp63 antibody, Trp63 antibody, tp63.L antibody
    Background
    This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), split-hand/foot malformation 4 (SHFM4), ankyloblepharon-ectodermal defects-cleft lip/palate, ADULT syndrome (acro-dermato-ungual-lacrimal-tooth), limb-mammary syndrome, Rap-Hodgkin syndrome (RHS), and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

    Cellular Localization: Nucleus
    Molecular Weight
    77 kDa
    Gene ID
    8626
    UniProt
    Q9H3D4
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