SOCS5 antibody (N-Term)

Catalog No. ABIN2855921

The Rabbit Polyclonal anti-SOCS5 antibody has been validated for WB and IHC (p). It is suitable to detect SOCS5 in samples from Human and Mouse. There are 2+ publications available.

Quick Overview for SOCS5 antibody (N-Term) (ABIN2855921)

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SOCS5 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Rat (Rattus), Pig (Porcine), Chicken, Rhesus Monkey, Cow (Bovine)

Cross-Reactivity (Details): Rat (100 %), Pig (100 %), Chicken (100 %), Rhesus Monkey (100 %), Bovine (100 %)

Characteristics: Rabbit Polyclonal antibody to SOCS5 (suppressor of cytokine signaling 5)
SOCS5 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SOCS5. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Comment:

Positive Control: Molt-4 , NT2D1 , PC-3 , mouse testis

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS, 40 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-SOCS5 antibody (ABIN2855921)

Cui, Chen, Zhang, Cheng, Pan, Huang, Hu, Zhang, Wang, Zhu, Chen, Liu, Zhao, Wu, Yang, Liu, Zhang, Yu, Yin, Jing, Rehman, Tian, Pan, Jia: "Duck Tembusu Virus Utilizes miR-221-3p Expression to Facilitate Viral Replication via Targeting of Suppressor of Cytokine Signaling 5." in: Frontiers in microbiology, Vol. 11, pp. 596, (2020) (PubMed).

Tsai, Kuo, Hung, Wu, Wu, Chang, Kuo, Hsu: "Angpt2 Induces Mesangial Cell Apoptosis through the MicroRNA-33-5p-SOCS5 Loop in Diabetic Nephropathy." in: Molecular therapy. Nucleic acids, Vol. 13, pp. 543-555, (2018) (PubMed).

Target Details for SOCS5

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Alternative Name: SOCS5

Background: The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.

Molecular Weight: 61 kDa

Gene ID: 9655

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process