CASQ2 antibody

Catalog No. ABIN2856218

The Rabbit Polyclonal anti-CASQ2 antibody has been validated for WB and IHC (p). It is suitable to detect CASQ2 in samples from Human.

Quick Overview for CASQ2 antibody (ABIN2856218)

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASQ2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CASQ2 Antibody

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit polyclonal antibody to Calsequestrin-2 (calsequestrin 2 (cardiac muscle))
Calsequestrin-2 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Calsequestrin 2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HCT116

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.68 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CASQ2

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Alternative Name: calsequestrin 2

Background: The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.

Cellular Localization: Sarcoplasmic reticulum lumen

Molecular Weight: 46 kDa

Gene ID: 845

UniProt: O14958

Pathways: Negative Regulation of Transporter Activity