RAMP1 antibody (C-Term)

Catalog No. ABIN2856616

Product Details anti-RAMP1 Antibody

Target: RAMP1 (Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAMP1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Rabbit polyclonal antibody to RAMP1 (receptor (G protein-coupled) activity modifying protein 1)
RAMP1 antibody [C1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RAMP1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HepG2 , mouse brain , rat brain

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.87 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for RAMP1

Target: RAMP1 (Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1))

Alternative Name: receptor activity modifying protein 1 (RAMP1 Products)

Synonyms: RAMP1 antibody, MGC147096 antibody, 9130218E19Rik antibody, receptor activity modifying protein 1 antibody, receptor (G protein-coupled) activity modifying protein 1 antibody, receptor (calcitonin) activity modifying protein 1 antibody, RAMP1 antibody, ramp1 antibody, Ramp1 antibody

Background: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.

Cellular Localization: Membrane, Single-pass type I membrane protein

Molecular Weight: 17 kDa

Gene ID: 10267

UniProt: O60894

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process