DUSP6 antibody

Catalog No. ABIN2856801

This anti-DUSP6 antibody is a Rabbit Polyclonal antibody detecting DUSP6 in WB. Suitable for Human.

Quick Overview for DUSP6 antibody (ABIN2856801)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DUSP6 Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Rabbit Polyclonal antibody to DUSP6 (dual specificity phosphatase 6)
DUSP6 antibody [N2C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human DUSP6. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Mouse liver , HepG2 , rat liver

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Alternative Name: dual specificity phosphatase 6

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Cytoplasm

Molecular Weight: 42 kDa

Gene ID: 1848

UniProt: Q16828

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades