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Perforin 1 antibody
PRF1
Reactivity: Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Perforin 1 Antibody
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Target
See all Perforin 1 (PRF1) Antibodies
Perforin 1 (PRF1)
(Perforin 1 (Pore Forming Protein) (PRF1))
Reactivity
All reactivities for Perforin 1 antibodies
Rat
Host
All hosts for Perforin 1 antibodies
Rabbit
Clonality
All clonalities for Perforin 1 antibodies
Polyclonal
Conjugate
All conjugates for Perforin 1 antibodies
This Perforin 1 antibody is un-conjugated
Application
All applications for Perforin 1 antibodies
Western Blotting (WB)
Cross-Reactivity
Mouse (Murine), Rat (Rattus)
Cross-Reactivity (Details)
Reacts with both rat and mouse perforin. Cross-reactivity to perforin of other species has not been tested.
Purification
purified
Immunogen
Perforin antibody was raised in rabbit using E. coli-expressed rat perforin as the immunogen.
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Alternatives
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Application Details
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Application Notes
WB: 1:1,000 Optimal conditions should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Lyophilized
Reconstitution
Reconstitue in distilled water.
Concentration
Lot specific
Buffer
Supplied as a lyophilized Potein A purified rabbit IgG with 0.1 % NaN3
Preservative
Sodium azide
Precaution of Use
This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
Target Details for Perforin 1
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Target
Perforin 1 (PRF1)
(Perforin 1 (Pore Forming Protein) (PRF1))
Alternative Name
Perforin (PRF1 Products )
Synonyms
FLH2 antibody, HPLH2 antibody, P1 antibody, PFN1 antibody, PFP antibody, PRF1 antibody, Pfn antibody, Pfp antibody, Prf-1 antibody, Cyta antibody, RATCYTA antibody, LOC443187 antibody, perforin antibody, prf1 antibody, cytolysin antibody, perforin-1 antibody, perforin-1-like antibody, perforin 1 antibody, perforin 1 (pore forming protein) antibody, perforin antibody, perforin 1 L homeolog antibody, PRF1 antibody, Prf1 antibody, LOC443187 antibody, prf1 antibody, prf1.L antibody
Background
Perforin-1 is a protein that in humans is encoded by the PRF1 gene. Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.
Pathways
Apoptosis , Caspase Cascade in Apoptosis
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