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ITGA4 antibody (PE)

This Mouse Monoclonal antibody specifically detects ITGA4 in FACS. It exhibits reactivity toward Human, Cow, Dog, Horse, Cat, Sheep and Non-Human Primate.
Catalog No. ABIN2869980

Quick Overview for ITGA4 antibody (PE) (ABIN2869980)

Target

See all ITGA4 Antibodies
ITGA4 (Integrin alpha 4 (ITGA4))

Reactivity

  • 136
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  • 31
  • 9
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  • 1
Human, Cow, Dog, Horse, Cat, Sheep, Non-Human Primate

Host

  • 76
  • 57
  • 27
Mouse

Clonality

  • 99
  • 62
  • 2
Monoclonal

Conjugate

  • 91
  • 13
  • 10
  • 10
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  • 4
  • 4
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  • 3
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  • 3
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  • 2
  • 1
  • 1
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  • 1
This ITGA4 antibody is conjugated to PE

Application

  • 82
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  • 4
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Flow Cytometry (FACS)

Clone

9F10
  • Purpose

    Anti-Hu CD49d PE

    Specificity

    The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.

    Cross-Reactivity (Details)

    Human, Non-Human Primates, Bovine, Canine (Dog), Equine (Horse), Feline (Cat), Sheep

    Purification

    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Isotype

    IgG1 kappa
  • Application Notes

    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

    Restrictions

    For Research Use only
  • Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Target

    ITGA4 (Integrin alpha 4 (ITGA4))

    Alternative Name

    CD49d

    Background

    Integrin subunit alpha 4,CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.,ITGA4, VLA-4 alpha

    Gene ID

    3676

    UniProt

    P13612

    Pathways

    Integrin Complex
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