APP antibody (pThr743, Thr668)

Catalog No. ABIN2883472

This Rabbit Polyclonal antibody specifically detects APP in WB, ELISA, IHC, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for APP antibody (pThr743, Thr668) (ABIN2883472)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APP Antibody

Binding Specificity: pThr743, Thr668

Specificity: Amyloid beta A4 (Phospho-Thr743/668) Antibody detects endogenous levels of Amyloid beta A4 only when phosphorylated at threonine743/668.

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide derived from human Amyloid beta A4 around the phosphorylation site of Thr743/668.

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: IF (1:100 - 1:500), IHC, IHC-P (1:50 - 1:100), Peptide-ELISA (1:10000), WB (1:500 - 1:1000)

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 150 mM sodium chloride, 0.02 % sodium azide, 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: APP / beta Amyloid

Background: Name/Gene ID: APP
Family: Amyloid precursor protein

Synonyms: APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II

Gene ID: 351

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour