CCL3 antibody (Biotin)

Catalog No. ABIN288450

The Biotin-conjugated Rabbit Polyclonal anti-CCL3 antibody (ABIN288450) specifically detects CCL3 in WB and ELISA. The antibody is reactive with Mouse samples.

Quick Overview for CCL3 antibody (Biotin) (ABIN288450)

Target: CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL3 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Product Details anti-CCL3 Antibody (Biotin)

Immunogen: MIP1 alpha antibody (biotin) was raised in rabbit using highly pure recombinant murine MIP-1 a as the immunogen.

Application Details

Application Notes: ELISA: 0.25-1 µg/mL, WB: 0.1-0.2 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in sterile PBS with 0.1 % BSA to a concentration of 50 µg/mL .

Concentration: Lot specific

Buffer: Lyophilized from PBS, pH 7.2.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Target Details for CCL3

Target: CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))

Alternative Name: MIP1 alpha

Background: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ, with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and Mouse MIP-1 alpha and MIP-1 beta are active on human and Mouse hematopoietic cells.

Molecular Weight: 7.8 kDa (predicted detection band MW)

Pathways: Cellular Response to Molecule of Bacterial Origin, Autophagy