Acetylcholinesterase antibody (AA 398-617)

Catalog No. ABIN3016743

The Rabbit Polyclonal anti-Acetylcholinesterase antibody has been validated for WB and IF. It is suitable to detect Acetylcholinesterase in samples from Human.

Quick Overview for Acetylcholinesterase antibody (AA 398-617) (ABIN3016743)

Target: Acetylcholinesterase (AChE)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetylcholinesterase antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Acetylcholinesterase Antibody

Binding Specificity: AA 398-617

Sequence: VPQVSDLAAE AVVLHYTDWL HPEDPARLRE ALSDVVGDHN VVCPVAQLAG RLAAQGARVY AYVFEHRAST LSWPLWMGVP HGYEIEFIFG IPLDPSRNYT AEEKIFAQRL MRYWANFART GDPNEPRDPK APQWPPYTAG AQQYVSLDLR PLEVRRGLRA QACAFWNRFL PKLLSATASE APSTCPGFTH GEAAPRPGLP LPLLLLHQLL LLFLSHLRRL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 398-617 of human ACHE (NP_056646.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Acetylcholinesterase

Target: Acetylcholinesterase (AChE)

Alternative Name: ACHE

Background: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.,ACHE,ACEE,ARACHE,N-ACHE,YT,Neuroscience,ACHE

Molecular Weight: 58 kDa/65 kDa/67 kDa

Gene ID: 43

UniProt: P22303

Pathways: Skeletal Muscle Fiber Development