Leptin Receptor antibody

Catalog No. ABIN3017146

Product Details anti-Leptin Receptor Antibody

Target: Leptin Receptor (LEPR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Leptin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide of human LEPR

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Leptin Receptor

Target: Leptin Receptor (LEPR)

Alternative Name: LEPR (LEPR Products)

Synonyms: CD295 antibody, LEP-R antibody, LEPRD antibody, OB-R antibody, OBR antibody, obr antibody, cd295 antibody, ob-rb antibody, Fa antibody, LEPROT antibody, Leprb antibody, Modb1 antibody, OB-RGRP antibody, Obr antibody, db antibody, diabetes antibody, obese-like antibody, obl antibody, ObRb antibody, Ob-R antibody, Ob-RM antibody, lepr antibody, leptin receptor antibody, leptin receptor S homeolog antibody, LEPR antibody, lepr antibody, Lepr antibody, lepr.S antibody

Background: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).,CD295,LEP-R,LEPRD,OB-R,OBR,LEPR,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Lipid Metabolism,AMPK Signaling Pathway,Endocrine and metabolic diseases,Obesity,Immunology & Inflammation,CD markers,Cardiovascular,Lipids,Fatty Acids,LEPR

Molecular Weight: 96 kDa/102 kDa/103 kDa/109 kDa/132 kDa

Gene ID: 3953

UniProt: P48357

Pathways: JAK-STAT Signaling, AMPK Signaling, Feeding Behaviour