STAT1 antibody (AA 513-712)

Catalog No. ABIN3020615

Product Details anti-STAT1 Antibody

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Binding Specificity: AA 513-712

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GLNVDQLNML GEKLLGPNAS PDGLIPWTRF CKENINDKNF PFWLWIESIL ELIKKHLLPL WNDGCIMGFI SKERERALLK DQQPGTFLLR FSESSREGAI TFTWVERSQN GGEPDFHAVE PYTKKELSAV TFPDIIRNYK VMAAENIPEN PLKYLYPNID KDHAFGKYYS RPKEAPEPME LDGPKGTGYI KTELISVSEV

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 513-712 of human STAT1 (NP_644671.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-STAT1 antibody (ABIN3020615)

Kong, Shen, Liu, Zuo, Ji, Lu, Nakamura, Lazarus, Stratakis, Breyer, Yu: "PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation." in: The Journal of experimental medicine, Vol. 213, Issue 10, pp. 2209-26, (2017) (PubMed).

Kong, Li, Shen, Liu, Zuo, Tao, Ji, Lu, Lazarus, Breyer, Yu: "Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1." in: The Journal of pharmacology and experimental therapeutics, Vol. 360, Issue 3, pp. 435-444, (2017) (PubMed).

Guo, Hu, Chen, Li, Ye, Cheng, Zhang, He: "iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus." in: Journal of proteomics, Vol. 130, pp. 65-75, (2016) (PubMed).

Target Details for STAT1

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Alternative Name: STAT1 (STAT1 Products)

Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.,CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91,STAT1 alpha,STAT1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,STAT1

Molecular Weight: 83 kDa/87 kDa

Gene ID: 6772

UniProt: P42224

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events