STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa)

Details for Product anti-STAT1 Antibody No. ABIN3020615
Antigen
  • CANDF7
  • ISGF-3
  • STAT91
  • 2010005J02Rik
  • AA408197
  • XStat1
  • STAT4
  • DD6G4-4
  • STAT
  • STAT1
  • dZ182H3.3
  • si:by134g18.2
  • si:by51f19.1
  • si:dz182h3.3
  • si:dz199m19.1
  • si:dz73o4.2
  • stat1
  • signal transducer and activator of transcription 1
  • signal transducer and activator of transcription 1 L homeolog
  • signal transducer and activator of transcription 1, 91kDa
  • signal transducer and activator of transcription 4
  • signal transducer and activator of transcription 1a
  • STAT1
  • Stat1
  • stat1.L
  • stat4
  • stat1a
Alternatives
anti-Human STAT1 antibody for Immunoprecipitation
Reactivity
Mouse (Murine), Rat (Rattus), Human
552
302
269
33
29
26
22
22
16
13
11
7
7
5
2
2
2
1
1
1
1
1
Host
Rabbit
475
106
2
1
1
Clonality
Polyclonal
Conjugate
This STAT1 antibody is un-conjugated
19
15
12
10
10
10
10
10
10
6
6
4
4
4
4
4
4
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
449
208
165
109
90
52
48
18
17
9
7
6
5
3
1
1
Options
Immunogen Recombinant protein of human STAT1
Isotype IgG
Purification Affinity purification
Plasmids, Primers & others Plasmids, Primers & others STAT1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name STAT1 (STAT1 Antibody Abstract)
Background The Stat1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-alpha and IFN-gamma. Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding. Stat1 protein exists as a pair of isoforms, Stat1alpha (91 kDa) and the splice variant Stat1beta (84 kDa). In most cells, both isoforms are activated by IFN-alpha, but only Stat1alpha is activated by IFN-gamma. The inappropriate activation of Stat1 occurs in many tumors. In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-alpha and other cellular stresses. Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation.
Synonyms: STAT1, DKFZp686B04100, ISGF-3, STAT91
Gene ID 6772
UniProt P42224
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C
Supplier Images
Immunofluorescence (IF) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) antibody (ABIN3020615) anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) antibody
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 1, 91kDa (STAT1) antibody (ABIN3020615) Western blot analysis of various cell lines, using STAT1 antibody.
Product cited in: Kong, Shen, Liu, Zuo, Ji, Lu, Nakamura, Lazarus, Stratakis, Breyer, Yu: "PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation." in: The Journal of experimental medicine, Vol. 213, Issue 10, pp. 2209-26, 2017 (PubMed). Method employed by authors: Western Blotting (WB)

Kong, Li, Shen, Liu, Zuo, Tao, Ji, Lu, Lazarus, Breyer, Yu: "Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1." in: The Journal of pharmacology and experimental therapeutics, Vol. 360, Issue 3, pp. 435-444, 2017 (PubMed). Method employed by authors: Western Blotting (WB)

Guo, Hu, Chen, Li, Ye, Cheng, Zhang, He: "iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus." in: Journal of proteomics, Vol. 130, pp. 65-75, 2016 (PubMed). Method employed by authors: Western Blotting (WB)

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