STAT1 antibody (Signal Transducer and Activator of Transcription 1, 91kDa)

Catalog No. ABIN3020615

Product Details anti-STAT1 Antibody

Target:

STAT1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human STAT1

Isotype: IgG

Application Details

Application Notes: Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C/-80 °C

References for anti-STAT1 antibody (ABIN3020615)

Kong, Shen, Liu, Zuo, Ji, Lu, Nakamura, Lazarus, Stratakis, Breyer, Yu: "PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation." in: The Journal of experimental medicine, Vol. 213, Issue 10, pp. 2209-26, 2017 (PubMed). Method employed by authors: Western Blotting (WB)

Kong, Li, Shen, Liu, Zuo, Tao, Ji, Lu, Lazarus, Breyer, Yu: "Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1." in: The Journal of pharmacology and experimental therapeutics, Vol. 360, Issue 3, pp. 435-444, 2017 (PubMed). Method employed by authors: Western Blotting (WB)

Guo, Hu, Chen, Li, Ye, Cheng, Zhang, He: "iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus." in: Journal of proteomics, Vol. 130, pp. 65-75, 2016 (PubMed). Method employed by authors: Western Blotting (WB)

Target Details for STAT1

Target:

STAT1

Alternative Name: STAT1 (STAT1 Antibody Abstract)

Synonyms: CANDF7, ISGF-3, STAT91, 2010005J02Rik, AA408197, XStat1, STAT4, DD6G4-4, STAT, STAT1, dZ182H3.3, si:by134g18.2, si:by51f19.1, si:dz182h3.3, si:dz199m19.1, si:dz73o4.2, stat1, signal transducer and activator of transcription 1, signal transducer and activator of transcription 1 L homeolog, signal transducer and activator of transcription 1, 91kDa, signal transducer and activator of transcription 4, signal transducer and activator of transcription 1a, STAT1, Stat1, stat1.L, stat4, stat1a

Background: The Stat1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-alpha and IFN-gamma. Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding. Stat1 protein exists as a pair of isoforms, Stat1alpha (91 kDa) and the splice variant Stat1beta (84 kDa). In most cells, both isoforms are activated by IFN-alpha, but only Stat1alpha is activated by IFN-gamma. The inappropriate activation of Stat1 occurs in many tumors. In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-alpha and other cellular stresses. Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation.
Synonyms: STAT1, DKFZp686B04100, ISGF-3, STAT91

Gene ID: 6772

UniProt: P42224

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events