MCL-1 antibody (AA 120-220)

Catalog No. ABIN3020788

The Rabbit Polyclonal anti-MCL-1 antibody has been validated for WB, IHC and IF. It is suitable to detect MCL-1 in samples from Human.

Quick Overview for MCL-1 antibody (AA 120-220) (ABIN3020788)

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCL-1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MCL-1 Antibody

Binding Specificity: AA 120-220

Sequence: MSPEEELDGY EPEPLGKRPA VLPLLELVGE SGNNTSTDGS LPSTPPPAEE EEDELYRQSL EIISRYLREQ ATGAKDTKPM GRSGATSRKA LETLRRVGDG V

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 120-220 of human MCL1 (NP_068779.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:100 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MCL-1

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Alternative Name: MCL1

Background: This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.,MCL1,BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S,Mcl-1,TM,bcl2-L-3,mcl1/EAT,MCL1,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Bcl 2 family,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Endocrine & Metabolism,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,MCL1

Molecular Weight: 28 kDa/37 kDa

Gene ID: 4170

UniProt: Q07820

Pathways: MAPK Signaling