GRB2 antibody (AA 198-217)

Catalog No. ABIN302091

This anti-GRB2 antibody is a Rabbit Polyclonal antibody detecting GRB2 in WB. Suitable for Human.

Quick Overview for GRB2 antibody (AA 198-217) (ABIN302091)

Target: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRB2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRB2 Antibody

Binding Specificity: AA 198-217

Purpose: Anti-GRB2 Purified

Specificity: The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa intracellular adaptor protein. The immunogen has 100 % identity between man, cow, rat and mouse.

Cross-Reactivity (Details): Human, Other species Not tested

Purification: Purified by ligand affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217).

Application Details

Application Notes: Western blotting: Recommended dilution: 1-2 μg/mL, reducing conditions.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for GRB2

Target: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Alternative Name: GRB2

Background: Growth factor receptor bound protein 2,Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.,ASH, NCKAP2

Gene ID: 2885

UniProt: P62993

Pathways: RTK Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation