IL-1 beta antibody (AA 1-269)

Catalog No. ABIN3021462

This Rabbit Polyclonal antibody specifically detects IL-1 beta in WB and IF. It exhibits reactivity toward Human and has been mentioned in 7+ publications.

Quick Overview for IL-1 beta antibody (AA 1-269) (ABIN3021462)

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-1 beta antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-IL-1 beta Antibody

Binding Specificity: AA 1-269

Sequence: MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL GGTKGGQDIT DFTMQFVSS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-269 of human IL1beta (NP_000567.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-IL-1 beta antibody (ABIN3021462)

Wu, Zhang, Qi, Zhang, Li, Li, Lin, Bai, Liu, Chen, Yang, Xu, Zhang, Yang: "Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis." in: Cell death & disease, Vol. 9, Issue 2, pp. 171, (2018) (PubMed).

Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." in: Pharmacological research, Vol. 133, pp. 218-235, (2018) (PubMed).

Zhou, Du, Liu, Zhao, Yuan, Li, Chen, Lu, Cheng, Liu: "Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity." in: Life sciences, Vol. 204, pp. 55-64, (2018) (PubMed).

Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." in: Frontiers in molecular neuroscience, Vol. 10, pp. 409, (2017) (PubMed).

Wang, Shi, Dou, Li, Shi, Jiang, Wang, Yu, Chen, Wang, Xiao, Hou, Feng, Shen, Ma, Han: "Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis." in: Immunology, Vol. 153, Issue 1, pp. 71-83, (2017) (PubMed).

Liu, Zhang, Cheng, Lu, Liu: "Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response." in: International journal of nanomedicine, Vol. 11, pp. 4875-4890, (2017) (PubMed).

Yang, Zhang, Wang, Zhang, Li: "Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis." in: Journal of periodontal research, Vol. 50, Issue 6, pp. 748-57, (2017) (PubMed).

Target Details for IL-1 beta

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Alternative Name: IL1B

Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.,IL-1,IL1-BETA,IL1F2,IL1 beta,IL1B,Cell Biology & Developmental Biology,Apoptosis,Growth factor,Endocrine & Metabolism,Endocrine and metabolic diseases,Obesity,Immunology & Inflammation,Cytokines,Interleukins,NF-kB Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Cardiovascular,IL1B

Molecular Weight: 30 kDa

Gene ID: 3553

UniProt: P01584

Pathways: NF-kappaB Signaling, Interferon-gamma Pathway, TLR Signaling, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome