IL-13 antibody (AA 25-146)

Catalog No. ABIN3022882

The Rabbit Polyclonal anti-IL-13 antibody has been validated for WB and IHC. It is suitable to detect IL-13 in samples from Human. There is 1 publication available.

Quick Overview for IL-13 antibody (AA 25-146) (ABIN3022882)

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-IL-13 Antibody

Binding Specificity: AA 25-146

Sequence: LTCLGGFASP GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGQ FN

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-IL-13 antibody (ABIN3022882)

Long, Chen, Zhao, Rafaels, Mathias, Liang, Potee, Campbell, Zhang, Gao, Georas, Vercelli, Beaty, Ruczinski, Mathias, Barnes, Chen: "An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum." in: PLoS ONE, Vol. 10, Issue 8, pp. e0135360, (2016) (PubMed).

Target Details for IL-13

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Alternative Name: IL13

Background: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.,IL13,IL-13,P600,Cancer,Tumor immunology,Immunology & Inflammation,Cytokines,Interleukins,Cell Intrinsic Innate Immunity Signaling Pathway,IL13

Molecular Weight: 15 kDa

Gene ID: 3596

UniProt: P35225

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport