CD70 antibody

Catalog No. ABIN3024471

The Mouse Monoclonal anti-CD70 antibody is suitable to detect CD70 in samples from Human. It has been validated for IHC, FACS and IF.

Quick Overview for CD70 antibody (ABIN3024471)

Target: CD70 (CD70 Molecule (CD70))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD70 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: BU69

Product Details anti-CD70 Antibody

Purpose: CD70 Antibody

Purification: Protein G affinity chromatography

Immunogen: The human WM-1 (Waldenstrom s macroglobulinemia) cell line was used as the immunogen for the CD70 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD70 antibody should be determined by the researcher.

1. This mAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the CD70 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background: CD70 belongs to the tumor necrosis factor (TNF) ligand family. It is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

UniProt: P32970

Pathways: Cancer Immune Checkpoints