PDE6A antibody (N-Term)

Catalog No. ABIN302532

The Rabbit Polyclonal anti-PDE6A antibody (ABIN302532) specifically detects PDE6A in IHC (p). The antibody is reactive with Human samples.

Quick Overview for PDE6A antibody (N-Term) (ABIN302532)

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6A antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PDE6A Antibody

Binding Specificity: N-Term

Specificity: This antibody detects Phosphodiesterase 6A (PDE6A) at N-terminal region.

Purification: Immunoaffinity chromatography

Immunogen: PDE6A antibody was raised against synthetic peptide from N-terminal region of human PDE6A / PDE6 Alpha.

Application Details

Application Notes: Immunohistochemistry on paraffin sections. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.23 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for PDE6A

Target: PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))

Alternative Name: PDE6A

Background: Phosphodiesterase 6A, a catalytic subunit of the photoreceptor phosphodiesterase, has been shown to affect functioning of eye retina as the alpha subunit of the heterotetrameric rod photoreceptor. Mutations in PDE6A have been identified as a cause of autosomal recessive retinitis pigmentosa.Synonyms: 5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6 alpha, PDEA, Phosphodiesterase 6A, Phosphodiesterase-6A cGMP-specific, Rod cGMP-specific 3'

Gene ID: 5145

NCBI Accession: NP_000431

UniProt: P16499

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction